Co-op Student, Guanine-quadruplex (G4) - BC Cancer Research Centre - Vancouver

Co-op Student, Guanine-quadruplex (G4) 

BC Cancer Research Centre

Vancouver, BC

Our laboratory has pioneered research into Guanine-quadruplex (G4) stabilisation as a novel cancer therapy. We discovered that the quinolone analogue CX5461 selectively kills BRCA1/2 mutant cancer cells by stabilising G4 structures in their DNA (Xu et al., 2017).

Building on Phase I/II clinical trial results (Hilton et al., 2022), we are now investigating how CX5461 and other G4-stabilising drugs impact the genome, transcriptome, and viability of cancer cells with DNA repair deficiencies. The ultimate goal is to harness G4 stabilization as a targeted therapy for tumors with defective DNA repair pathways.

What you’ll do:

As a co-op student in our laboratory, you will gain hands-on experience in cutting-edge molecular and cellular techniques used in cancer research. Your key responsibilities will include:

• Mammalian cell culture – Growing and treating cancer cells with small-molecules and drugs.
• Molecular assays – Performing DNA damage and cell viability assays to assess drug effects.
• Data analysis & experimental design – Analysing results, formulating hypotheses, and planning follow-up experiments to validate findings.

By the end of rotation, students will: 

• Demonstrate a deep understanding of cancer genomics, the role of DNA repair deficiencies in tumour progression, and the scientific rationale behind G4 stabilisation as a therapeutic strategy.
• Develop expertise in experimental techniques commonly used in molecular oncology, including cell culture, DNA damage assays, and viability measurements.
• Generate high-quality data that meets standards for inclusion in a scientific publication.
• Critically analyse experimental results, identifying potential pitfalls, proposing alternative interpretations, and designing control experiments.
• Formulate and test hypotheses using data-driven insights and literature review, designing follow-up experiments to refine findings.
• Present findings effectively through clear data visualisation and logical scientific communication.

Core Competencies:

• Brings an understanding of the Indigenous specific racism and the broader systemic racism that exists in the colonial health care structure, and has demonstrated initiatives in breaking down barriers and ensuring a safe environment ensuring a sense of belonging to all and informed by Indigenous Cultural Safety.
• Awareness of social, economic, political and historical realities of settler colonialism on Indigenous Peoples and familiarity with addressing Indigenous-specific anti-racism, anti-racism and Indigenous Cultural Safety and foundational documents and legislative commitments (the Declaration Act, the Declaration Action Plan, TRC, IPS, Remembering Keegan, etc.).

You have:

• Demonstrates a commitment to beginning and/or continuing their personal learning journey related to Indigenous-specific racism and dismantling systems of oppression, as well as addressing racism more broadly. Shows willingness to articulate and share their learning experiences to contribute to a culture of motivation and inspiration among peers.
• Demonstrates foundational knowledge of the social, economic, and political realities of settler-colonialism and its impacts on Indigenous peoples and equity-deserving groups within social and health contexts. Understands the impact of social determinants of health-on-health outcomes. Shows a commitment to learning about and upholding legislative obligations and provincial commitments outlined in foundational documents such as the Truth & Reconciliation Commission’s Calls to Action (2015), In Plain Sight (2020), BC's Declaration on the Rights of Indigenous Peoples Act (2019), United Nations Declaration on the Rights of Indigenous Peoples (UNDRIP), Reclaiming Power and Place: Missing and Murdered Indigenous Women & Girls Calls for Justice (2019), the Declaration Act Action Plan, Remembering Keegan: A First Nations Case Study, the BC Human Rights Code, Anti-Racism Data Act, and the Distinctions Based Approach.

What we bring

Every PHSA employee enables the best possible patient care for our patients and their families. Whether you are providing direct care, conducting research, or making it possible for others to do their work, you impact the lives of British Columbians today and in the future. That’s why we’re focused on your care too – offering health, wellness, development programs to support you – at work and at home.

• Join one of BC’s largest employers with province-wide programs, services and operations – offering vast opportunities for growth, development, and recognition programs that honour the commitment and contribution of all employees.
• Access to professional development opportunities through our in-house training programs, including +2,000 courses, such as our San’yas Indigenous Cultural Safety Training course, or Core Linx for Leadership roles.
• PHSA is a remote work friendly employer, welcoming flexible work options to support our people (eligibility may vary, depending on position).
• Access to WorkPerks, a premium discount program offering a wide range of local and national discounts on electronics, entertainment, dining, travel, wellness, apparel, and more.

Job Type: Casual (8 months)

Wage: Starting wage for this position would be determined with consideration of the successful candidate’s relevant education and experience and would be in alignment with the provincial compensation reference plan. 

Location: 675 West 10th Avenue, Vancouver BC, V5Z 1G1

Applications will be accepted until position is filled.

Hours of Work: Monday – Friday; 0830-1630

Requisition Number: 183831E

What we do

BC Cancer provides comprehensive cancer control for the people of British Columbia. BC Cancer is part of the Provincial Health Services Authority (PHSA).

PHSA plans, manages and evaluates specialized health services with the BC health authorities to provide equitable and cost-effective health care for people throughout the province. Our values reflect our commitment to excellence and include: Respect people – Be compassionate – Dare to innovate – Create equity – Be courageous.

Learn more about PHSA and our programs: jobs.phsa.ca/programs-and-services

PHSA and BC Cancer are committed to anti-racism and equity in our hiring and employment practices. With learning and compassion, we are addressing existing inequities and barriers throughout our systems. PHSA is seeking to create a diverse workforce and to establish an inclusive and culturally safe environment. We invite applications and enquiries from all people, particularly those belonging to the historically, systemically, and/or persistently excluded groups identified under the B.C. Human Rights Code.

One of PHSA’s North Star priorities is to eradicate Indigenous-specific racism, which includes ongoing commitments to Indigenous recruitment and employee experience as well as dismantling barriers to health care employment at every level. We welcome Indigenous individuals to apply and/or contact the Sanya’k̓ula Team (Indigenous Recruitment & Employee Experience) for support at indigenous.employment@phsa.ca.

Indigenous-specific anti-racism initiatives are rooted in addressing the unique forms of discrimination, historical and ongoing injustices, and exclusion faced by Indigenous peoples. These initiatives align with an Indigenous rights-based approach, recognizing the inherent rights and title of BC First Nations and self-determination of all First Nations, Inuit and Métis communities. PHSA is mandated to uphold legislative obligations and provincial commitments found in the foundational documents including the Truth & Reconciliation Commission’s Calls to Action (2015), In Plain Sight (2020), BC's Declaration on the Rights of Indigenous Peoples Act (2019), United Nations Declaration on the Rights of Indigenous Peoples (UNDRIP), Reclaiming Power and Place Missing and Murdered Indigenous Women & Girls Calls for Justice (2019), the Declaration Act Action Plan and Remembering Keegan: A First Nations Case Study.

Reconciliation is an ongoing process and a shared responsibility for all of us. The BC Governments’ unanimous passage of the Declaration on the Rights of Indigenous Peoples Act was a significant step forward in this journey—one that all health authorities are expected to support as we work in cooperation with Indigenous Peoples to establish a clear and sustainable path to lasting reconciliation. True reconciliation will take time and ongoing commitment to work with Indigenous Peoples as they move toward self-determination. Guiding these efforts Crown agencies must remain focused on creating opportunities that implement the Truth and Reconciliation Commission Mandate.

Attention current employees of PHSA:  

You must apply via your internal profile at http://internaljobs.phsa.ca.

The internal job posting expires on May 23, 2025, and will no longer be accessible. If the internal job posting has expired, please e-mail internaljobshelpu@phsa.ca with the six-digit job requisition number and your PHSA employee ID number to be considered as a late internal applicant. Please do not apply for the external job posting.

If you have not yet set up an internal profile, please e-mail internaljobshelpu@phsa.ca with your PHSA employee ID number to obtain your temporary password. Our business hours are Monday-Friday 8:30am-4:30pm, excluding Statutory Holidays and a Help Desk Representative will respond to you with 1-2 business days. 

If you are not a current employee of PHSA and require assistance with your application, please contact the External Careers team at careers@phsa.ca.